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%ما هو (من)٪ 1 - تعريف
Tyrosine hydroxylase
![Tyrosine hydroxylase catalyzes the rate limiting step in [[catecholamine]] biosynthesis](https://commons.wikimedia.org/wiki/Special:FilePath/Catecholamines biosynthesis.svg?width=200 "Tyrosine hydroxylase catalyzes the rate limiting step in [[catecholamine]] biosynthesis")
![substrate]] would enter from.](https://commons.wikimedia.org/wiki/Special:FilePath/Tyrosine hydroxylase from rat showing two of its domains.png?width=200 "substrate]] would enter from.")
MAMMALIAN PROTEIN FOUND IN HOMO SAPIENS
Tyrosine 3-monooxygenase; Tyrosine hydroxylase inhibitor; Tyrosine-3-hydroxylase; EC 1.14.16.2; Tyrosine 3-hydroxylase; L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)
Tyrosine hydroxylase or tyrosine 3-monooxygenase is the enzyme responsible for catalyzing the conversion of the amino acid L-tyrosine to L-3,4-dihydroxyphenylalanine (L-DOPA). It does so using molecular oxygen (O2), as well as iron (Fe2+) and tetrahydrobiopterin as cofactors.
Tyrosine N-monooxygenase
CLASS OF ENZYMES
EC 1.14.13.41; Tyrosine N-hydroxylase; CYP79A1; L-tyrosine,NADPH:oxygen oxidoreductase (N-hydroxylating); L-tyrosine,NADPH:oxygen oxidoreductase
Tyrosine N-monooxygenase (, tyrosine N-hydroxylase, CYP79A1) is an enzyme with systematic name L-tyrosine,NADPH:oxygen oxidoreductase (N-hydroxylating). This enzyme catalyses the following chemical reaction
Tyrosine hydroxylase deficiency
![L-3,4-dihydroxyphenylalanine]]; MN, metanephrine; MAO, [[monoamine oxidase]]; MPHG, 3-methoxy-4-hydroxyphenylethylene glycol; NMN, normetanephrine; PAH, phenylalanine hydroxylase; PLP, pyridoxal phosphate; PNMT, phenylethanolamine N-methyltransferase; TH, tyrosine hydroxylase; TPH, tryptophan hydroxylase. From a review by Gyrid Nygaard et al., 2021.<ref name="pmid34834538"/>](https://commons.wikimedia.org/wiki/Special:FilePath/Simplified overview of the biosynthesis and catabolism of serotonin and the catecholamines TH circled in red.jpg?width=200 "L-3,4-dihydroxyphenylalanine]]; MN, metanephrine; MAO, [[monoamine oxidase]]; MPHG, 3-methoxy-4-hydroxyphenylethylene glycol; NMN, normetanephrine; PAH, phenylalanine hydroxylase; PLP, pyridoxal phosphate; PNMT, phenylethanolamine N-methyltransferase; TH, tyrosine hydroxylase; TPH, tryptophan hydroxylase. From a review by Gyrid Nygaard et al., 2021.<ref name=\"pmid34834538\"/>")
Tyrosine hydroxylase deficiency (THD) is a disorder caused by disfunction of tyrosine hydroxylase, an enzyme involved in the biosynthesis of dopamine. This condition is one of the causes of dopa-responsive dystonia.
